Effect of Aspirin on the Thrombelastogram of Human Blood

G de Gaetano; J Vermylen

doi:10.1055/s-0038-1649127

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 30(03): 494-498
DOI: 10.1055/s-0038-1649127

Original Article

Schattauer GmbH

Effect of Aspirin on the Thrombelastogram of Human Blood

G de Gaetano^*

¹Laboratory of Blood Coagulation, Medical Research Department, Academisch Ziekenhuis St. Rafael, University of Leuven, Belgium

,

J Vermylen

¹Laboratory of Blood Coagulation, Medical Research Department, Academisch Ziekenhuis St. Rafael, University of Leuven, Belgium

› Author Affiliations

Abstract

Summary

Thrombelastograms of both native blood and re-calcified platelet-rich plasma samples taken from subjects given a single oral dose of aspirin (1 gram) were not significantly different from the pretreatment recordings. Aspirin also did not modify the thrombelastogram when preincubated in vitro with platelet-rich plasma at concentrations inhibiting the platelet “release reaction” by collagen. Thrombelastography therefore cannot evaluate the effect of aspirin on platelet function.

Full Text

References

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